Enrichment and analysis of glycated proteins
نویسندگان
چکیده
Abstract Glycation is a spontaneous post-translational modification of lysine, arginine, and the N-terminus proteins. Protein glycation closely related to pathogenesis human diseases, including diabetes, Alzheimer’s disease, renal cancer. The levels advanced end products (AGEs) are positively correlated with progression many diseases. However, it remains challenging analyze glycation-related products, such as reactive carbonyl species, Schiff bases, Amadori compounds, AGEs, because their high heterogeneity. Many analysis methods, fluorescence detection, immunoassays, liquid chromatography-tandem mass spectrometry, have attempted correlate Some enrichment methods been used increase probability detection glycated proteins due low abundance in blood plasma. This review summarizes that currently identify disease biomarker exploratory studies.
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ژورنال
عنوان ژورنال: Reviews in Analytical Chemistry
سال: 2022
ISSN: ['2191-0189', '0793-0135']
DOI: https://doi.org/10.1515/revac-2022-0036